Bulk
Drugs Manufacturing viz.
lycopene, phycocyanin
Technology/Process Description:
Beta
Carotene:
Beta-carotene
is a member of the carotenoid family. Carotenoids are yellow-to-red pigments
found in all green plant tissues and in some species of algae. So far 21
different carotenoids have been found in human blood. The most abundant ones
are alpha-carotene, beta-carotene, lutein, lycopene, cryptoxanthin and
zeaxanthin. A molecule of alpha-carotene, beta-carotene, or cryptoxanthin can
be split into two molecules of vitamin A in the body but the conversion of
beta-carotene is by far the most effective. They are very effective in
neutralizing a highly reactive for of oxygen called singlet oxygen. Low levels
of beta-carotene in their blood have a higher incidence of heart disease and
cancer, particularly lung cancer. The National Cancer Institute endorsed a
study which found that Beta carotene lower chance of getting cancer, including
breast cancer.
Natural beta
carotene is used not only as a bountiful source of Vitamin A but also for
reducing cholesterol and lipid levels, protection against strokes and
cataracts, enhancing the immune system, preventing certain photo sensitivity
disorders, improving antioxidant action and intra cellular communication,
quenching singlet oxygen and dramatically reducing stress.
Natural
Beta-carotene consists of two isomers. One is all trans isomer and other is 9
cis. In experiments, Ben-Amotz found that the natural 9-cis is the potent
antioxidant that rapidly quenches free radicals. It gives natural beta-carotene
a powerful advantage over the synthetic.
More recent research suggests that
beta-carotene's prevention effect is due to its antioxidant property. It is
extremely useful in the immune enhancement, mental functioning, arthritis and
prostate cancer.
Lycopene:
Lycopene is
a powerful antioxidant carotenoid and the pigment that gives tomatoes, watermelon,
and pink grapefruit their characteristic red color. Clinical studies have
indicated that Lycopene works through a number of mechanisms to support
cardiovascular health and immune function. In addition, epidemiological studies
have determined that lycopene may be particularly important for the support of
prostate health, as well as for the health of the digestive tract.
Lycopene
Molecular weight = 536.89
Exact Mass= 536
Molecular Formula= C40H56
Molecular Composition= C 89.49% H 10.51%
It is a crystalline substance,
C40H56, that is the main pigment of certain fruits, as the tomato and paprika,
and is a precursor to carotene in plant biosynthesis.
Lycopene fights destructive
"free radicals." Lycopene prevents oxidation of low-density
lipoprotein (
Technology/Product Specifications:
PRODUCT
1: 30%
Usage: Beta-carotene is used in foods to
provide color. It is sometimes added to products for its anti-oxidant effects,
to keep fats from going rancid. It is sometimes added to foods or vitamin
supplements as a nutrient. The long chains of conjugated double bonds that give
the carotene strong color. It can mop up oxygen free radicals and dissipate
their energy.
Product Specifications
|
Total Carotenoids |
30%
minimum |
|
Alpha-Carotene
1.0-2.0% typical |
|
|
Beta-
Carotene 25.0-27.0% typical |
|
|
Lutein
0.5-0.8% typical |
|
|
Zeaxanthin
0.5-0.8% typical |
|
|
Cryptoxanthin
0.05-0.08% typical |
|
|
Other
Carotenoids 0.6-2.0% typical. |
|
|
Vitamin A Activity |
Each
gram of this product contains not less than 420,000 I.U. of vitamin A
activity. Biological activity: 1 mg of beta-carotene = 1,670 I.U. of vitamin
A activity. (Martindale. The extra Pharmacopoeia, 30’th ed, Pg.1051) |
|
Isomeric Form |
Approximately
60% typical |
|
cis-isomers
and 40% typical transisomers. |
|
|
Solubility |
Soluble
in oil and fats. Insoluble in water. Partially soluble in ethanol. |
|
Peroxide value |
10meg/kg
max |
|
Moisture |
1.0%
max. |
|
Microbiology |
Total
aerobic microbial count. 1000/g.max |
|
Stability |
POLYCAROTENE
30% is stabilized with 0.35 natural tocopherols. Its shelf life is 24 months
when stored in cool and dry place in unopened original containers |
|
Uses |
As
dietary supplements and nutrient. |
|
Packaging |
POLYCAROTENE
30% is available in 1.0kg and 5.0kg container under nitrogen. |
|
Labeling |
Products
formulated using POLYCAROTENE 30% can be labeled as containing “all natural”
or “natural-source” carotenoids. |
|
Storage |
POLYCAROTENE
30% is sensitive to air, light and heat. Store in tightly closed containers. |
|
Other
variants available: 7.5%, 15% and 20% |
|
PRODUCT 2:
LYCOPENE /TOMATO OLERESIN
Lycopene is an open-chain unsaturated
carotenoid that imparts red color to tomatoes, guava, rosehip, watermelon and
pink grapefruit. Lycopene is a proven antioxidant.
Specifications:
Plant Origin: Lycopersicon
esculentum
Molecular Formula: Open chain unsaturated carotenoid
Specification: 6%/10%
HPLC Oil
|
Plant
part |
Fruit
Extract |
|
Solvent |
Ethanol |
|
Water
Carrier Used |
None |
|
Appearance |
Oil
suspension |
|
Color |
Reddish
yellow |
|
Odor |
Characteristic |
|
Taste |
Characteristic
|
|
Solubility |
Unsolvable
in water, sparingly in carbinol, ethanol, soluble in ether, own alkane,
acetone, easily soluble in chloroform, benzene, sulphurate carbons |
|
Heavy
Metals |
<20ppm |
|
Arsenic: |
<1ppm |
|
Assay
Lycopene by HPLC |
> 6% |
|
Total
Plate count |
1,000cfu/G |
|
Yeast
& Mold |
<100cfu/G |
|
E.Coli |
Negative |
|
Salmonella |
Negative |
|
Shelf
life |
Two years
when properly stored |
|
Storage |
Tightly
seal in clean, cool and dry area. |
Lycopene Crystal
|
Synonyms |
Tomato
oleoresin |
|
Molecular
formula |
open-chain
unsaturated carotenoid |
|
Appearance |
Dark red
needle like crystal |
|
Odor |
Characteristic |
|
Taste |
Peculiar |
|
Solubility |
Unsolvable
in water, sparingly in carbinol, ethanol, soluble in aether, own alkane, acetone,
easily soluble in chloroform, benzene, sulphurate carbons |
|
Heavy
metal |
<= 10
ppm |
|
Mercury |
< 2PPM |
|
Lead |
< 2PPM |
|
Total
plate count |
<
2000/gr |
|
E-coil |
Negative
in 1 gr |
|
Salmonclla |
Negative
in 20 gr |
|
Shigella |
Absent |
|
Yeast
& mould |
<= 1000
cfu/g |
|
Colon
bacillus |
No |
|
Storage |
Refrigerate
or freeze |
Company Profile
|
Company Name |
ABL Biotechnologies Ltd. |
|
Address |
55, 3rd East Street, Kamaraj
Nagar, Thiruvanmiyur,Chennai-600041, Tamil Nadu, India |
|
Contact person |
Mr. T. Surya Kumar |
|
Phone |
+91-44-42020501,42020502 |
|
Fax |
+91-44-42020501,42020502 |
|
E-mail |
|
|
Web Site |
|
|
Year of Establishment |
1992 |
|
Product(s) Manufactured |
Bulk Drugs- 30% Beta Carotene,
Phycocyanin, |
|
Production (FY-05) (Products
contributing most to the sales) |
30% Beta Carotene 600 Kg |
|
Sales Turnover |
FY 05: USD 1.7 Mn FY 04: USD 1.1 Mn FY 03: USD 0.8 Mn |
|
Conformity to Standards |
Nil |
|
Compliance to ISO |
Nil |
|
Foreign Collaboration |
Nil |
|
Manpower Total (Nos.) |
150 |
|
Raw Materials / Equipment used |
Spray Drier, Centrifuges, Race way,
Content Testing, Quality Testing |
|
Effluent Generated |
Non Polluting |
Broad Profile of Project
Offer
|
Project |
To Manufacture Bulk Drugs
viz. Beta Carotene, Lycopene, Phycocyanin |
|
Capacity per Annum |
·
Phycocyanin 1.2 Ton ·
10%
Lycopene 1.2-1.5 Ton ·
30%
Beta Carotene 600 Kg. |
|
Land Requirements/ Building Requirements |
20,000 Sq. M |
|
Plant & Machinery and Test
Equipment |
Raw Material depending upon Drug, Spray Drier,
Centrifuges, Race way, Content Testing, Quality Testing |
|
Electrical Installation |
120 HP |
|
Implementation Period |
5 Months |
|
Manpower Required |
150 |
|
Raw Materials / Equipment Required |
Spray Drier, Centrifuges, Race way, Content Testing,
Quality Testing |
|
Total Project Cost |
USD 2.5 Mn
(Approx.) |
|
Expected Annual Sales |
USD 0.25 Mn |
|
Profitability |
25% |
|
Form of Offer |
Turnkey Project |